PSB-603

Research use only, not for human use.

Adenosine A2B receptor antagonist.

Adenosine A2B receptor antagonist.(In Vitro):In peripheral T cells, PSB-603 (100 nM) inhibits NECA-stimulated IL-6 release about 3-fold. PSB-603 (10 μM) shows no affinity for the human and rat A1 and A2A and human A3 receptors.(In Vivo):PSB-603 (5 mg/kg; i.p.) significantly reduces inflammation in local and systemic mice models of inflammation. In the inflamed paw, PSB-603 significantly decreases the levels of the inflammatory cytokines including IL-6, TNF-α and of ROS. PSB-603 reduces inflammation of the peritoneum by decreasing the infiltration of leukocytes.

PSB 603

Others

Other Targets

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1092351-10-4

529.0

C24H25ClN6O4S

>98% (HPLC)

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CCCn1c(O)nc2nc([nH]c2c1=O)-c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(Cl)cc1

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(-20℃)

With Ice Pack

≥ 2 years