Vopratelimab (JTX-2011) is a selective humanized immunoglobulin G1-kappa monoclonal antibody and a potent ICOS agonist with high affinity for inducible T cell co-stimulating factors (ICOS), showing affinities of 0.93 nM for hICOS, 3.7 nM for rat ICOS, and 0.64 nM for mICOS.

[Ser25] - PKC (19 - 36) Substrate

Calcium dobesilate(CaD) has angioprotective properties and protects endothelial cells partly by ameliorating HG?induced inflammation.