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PRN371
CAS No. 1610974-55-4
PRN371( PRN 371 )
Catalog No. M12331 CAS No. 1610974-55-4
PRN371 is a novel potent, selective JAK3 inhibitor with IC50 of 0.5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePRN371
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NoteResearch use only, not for human use.
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Brief DescriptionPRN371 is a novel potent, selective JAK3 inhibitor with IC50 of 0.5 nM.
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DescriptionPRN371 is a novel potent, selective JAK3 inhibitor with IC50 of 0.5 nM, displays >250-fold selectivity over JAK1, JAK2, and TYK2; effectively inhibits IL-2 induces JAK1/3-STAT5 phosphorylation in PBMCs with IC50 of 99 nM, effectively blocks JAK3-mediated signaling in JAK3-driven cancer cells; effectively inhibits the growth of NKTL cells via suppressing the JAK3-STAT pathway, and exhibits a more durable inhibition on JAK3 compared to tofacitinib in vitro; significantly inhibits tumor growth in NKTL xenograft model harboring JAK3 activating mutation.
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In Vitro——
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In Vivo——
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SynonymsPRN 371
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PathwayAngiogenesis
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TargetJAK
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RecptorJAK
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Research Area——
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Indication——
Chemical Information
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CAS Number1610974-55-4
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Formula Weight363.421
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Molecular FormulaC20H21N5O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name2-(3-acrylamidophenyl)-N-(tert-butyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nairism?gi M-, et al. Leukemia. 2018 Feb 2. doi: 10.1038/s41375-017-0004-x.
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