PQ-912( PQ 912 | PQ912 )

Catalog No. M11147 CAS No. 1276021-65-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PQ-912
Note

Research use only, not for human use.
Brief Description

PQ-912 (PQ 912, PQ912)?is a potent glutaminyl cyclase (QC) inhibitor that inhibits human, rat, and mouse QC with Ki of 20-65 nM.
Description

PQ-912 (PQ 912, PQ912)?is a potent glutaminyl cyclase (QC) inhibitor that inhibits human, rat, and mouse QC with Ki of 20-65 nM; shows a favourable profile of the compound for QC engagement coupled to a reduction of pE-Aβ and behavioural improvementsthe first in class inhibitor of glutaminyl cyclases currently being in clinical development for Alzheimer's disease.Alzheimer Disease Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

PQ 912 | PQ912
Pathway

Others
Target

Other Targets
Recptor

Other Targets
Research Area

Neurological Disease
Indication

Alzheimer Disease

CAS Number

1276021-65-8
Formula Weight

336.395
Molecular Formula

C19H20N4O2
Purity

>98% (HPLC)
Solubility

DMSO : 200 mg/mL 594.55 mM
SMILES

O=C1NC[C@H](C2=CC=C(OCCC)C=C2)N1C3=CC=C4C(NC=N4)=C3
Chemical Name

(S)-1-(1H-benzo[d]imidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one

1. Hoffmann T, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):119-130.

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