PMX53

Research use only, not for human use.

PMX53 (Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg)) is a potent C5a receptor (CD88) antagonist with IC50 of 20 nM.

PMX53 (Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg)) is a potent C5a receptor (CD88) antagonist with IC50 of 20 nM, also is an agonist for Mas-related gene 2 (MrgX2) in human mast cells; PMX-53 (10 nM) inhibited C5a-induced Ca(2+) mobilization in HMC-1 cells, but at higher concentrations (>30 nM) it caused degranulation in LAD2 mast cells, CD34(+) cell-derived mast cells, and RBL-2H3 cells stably expressing MrgX2; inhibits zymosan-, carrageenan-, LPS- and antigen-induced hypernociception in rats.

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Animal Model:Adult male Wistar rats (weighing 180-200?g) injected with zymosan Dosage:0.3 mg/kg, 1 mg/kg or 3?mg/kg Administration:Subcutaneous injection; once Result:Inhibited the hypernociception induced by zymosan-activated serum and C5a.

PMX 53 | Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg

Immunology/Inflammation

Complement System

Complement System

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219639-75-5

896.1

C47H65N11O7

>98% (HPLC)

In Vitro:?DMSO : 200 mg/mL (223.19 mM)

N=C(NCCC[C@H](NC([C@@H](NC([C@H](NC([C@H]1N(CCC1)C([C@@H](NC([C@@H](NC(C)=O)CC2=CC=CC=C2)=O)CCCN3)=O)=O)CC4CCCCC4)=O)CC5=CNC6=C5C=CC=C6)=O)C3=O)N

Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg)

(-20℃)

With Ice Pack

≥ 2 years