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Home - Products - JAK/STAT Signaling - STAT - PM-43I

PM-43I

CAS No. 1637532-77-4

PM-43I( PM-43-I )

Catalog No. M12467 CAS No. 1637532-77-4

PM-43I is a selective inhibitor of STAT5/6 Src Homology 2 (SH2) domain.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    PM-43I
  • Note
    Research use only, not for human use.
  • Brief Description
    PM-43I is a selective inhibitor of STAT5/6 Src Homology 2 (SH2) domain.
  • Description
    PM-43I is a selective inhibitor of STAT5/6 Src Homology 2 (SH2) domain, binds recombinant STAT6 and STAT5B (IC50=1.8 and 3.8 uM) with much lower affinity for STAT3 (IC50=29.9 uM); potently inhibits both STAT5- and STAT6-dependent allergic airway disease in mice; PM-43I reverses preexisting allergic airway disease in mice with a minimum ED50 of 0.25 μg/kg.
  • In Vitro
    Western Blot Analysis Cell Line:Beas-2B immortalized human airway cells Concentration:0.05, 0.1, 0.5, 1, 2.5, 5 μM Incubation Time:2 h Result:Inhibited STAT6 phosphorylation level to 18%, 21% at 2.5 and 5 μM, respectively.
  • In Vivo
    PM-43I (intranasal administration; 5 μg per mouse; every other day; 18 d) activity is restricted to the lung by intranasal administration. Animal Model:Mice injected with Ovalhumin/Alum Dosage:5 μg per mouse Administration:Intranasal administration; 5 μg per mouse; every other day; 18 days Result:Showed no effect on the sensisization of peripheral spleenocytes to ovalbumin.
  • Synonyms
    PM-43-I
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1637532-77-4
  • Formula Weight
    559.559
  • Molecular Formula
    C30H30N3O6P
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 35 mg/mL (45.00 mM)
  • SMILES
    O=P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)C(F)(F)C1=CC=C(/C(C)=C/C(N[C@@H]2C(N(CC(N(C)C3=CC=CC=C3)=O)CCCC2)=O)=O)C=C1
  • Chemical Name
    (4-((E)-4-(((3S,6S)-6-(methyl(phenyl)carbamoyl)-4-oxo-1,2,3,4,6,7-hexahydroazepino[3,2,1-hi]indol-3-yl)amino)-4-oxobut-2-en-2-yl)phenyl)phosphonic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Knight JM, et al. J Biol Chem. 2018 May 8. pii: jbc.RA117.000567.
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