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PLX-8394
CAS No. 1393466-87-9
PLX-8394( PLX 8394 )
Catalog No. M11639 CAS No. 1393466-87-9
A potent and selective Raf inhibitor with biochemical IC50 of 3.8/14/23 nM for BRaf V600E/BRAF/CRAF, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | In Stock |
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| 10MG | 129 | In Stock |
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| 25MG | 232 | In Stock |
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| 50MG | 345 | In Stock |
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| 100MG | 503 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePLX-8394
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective Raf inhibitor with biochemical IC50 of 3.8/14/23 nM for BRaf V600E/BRAF/CRAF, respectively.
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DescriptionA potent and selective Raf inhibitor with biochemical IC50 of 3.8/14/23 nM for BRaf V600E/BRAF/CRAF, respectively; shows pERK inhibition in A375 and COLO829 cells with IC50 of 3.5 nM and 2.1 nM, respectively; and do not elicit paradoxical ERK1/2 activation in mutant RAS expressing cells; exhibits effectivity in both BRAFV600E and certain non-V600 LA models, in vitro and in vivo.Skin Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsPLX 8394
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PathwayMAPK/ERK Signaling
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TargetRaf
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RecptorBRAFV600E|BRAF
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Research AreaCancer
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IndicationSkin Cancer
Chemical Information
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CAS Number1393466-87-9
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Formula Weight542.5328
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Molecular FormulaC25H21F3N6O3S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 39 mg/mL
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SMILESO=S(N1C[C@H](F)CC1)(NC2=CC=C(F)C(C(C3=CNC4=NC=C(C5=CN=C(C6CC6)N=C5)C=C43)=O)=C2F)=O
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Chemical Name1-Pyrrolidinesulfonamide, N-[3-[[5-(2-cyclopropyl-5-pyrimidinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-3-fluoro-, (3R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tutuka CSA, et al. Mol Cancer. 2017 Jun 28;16(1):112.
2. Zhang C, et al. Nature. 2015 Oct 22;526(7574):583-6.
3. Okimoto RA, et al. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13456-13461.
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