PLGA

Research use only, not for human use.

PLGA is be used to fabricate devices for drug delivery and tissue engineering applications.

PLGA is be used to fabricate devices for drug delivery and tissue engineering applications.

Cell Viability Assay Cell Line:Calu-3 cellsConcentration:0.03-5 mg/mL (for PLgA (75:25)/PVA and PLgA (75:25)/CS); 3-5 mg/mL (for PLgA (75:25)/CS and PLgA (75:25)/PF68); 0.03-1 mg/mL (for PLgA (75:25)/PVA and PLgA (75:25)/PF68) (CS (chitosan), PF68 and PVA (poly vinyl alcohol) serve as cationic stabilizer)Incubation Time:72 h Result:Showed low toxicity to cells (cell viability was always higher than 50%) even at the highest concentration tested, when xposured to PLgA (75:25)/PVA, PLgA (75:25)/CS and PLgA (75:25)/PF68 nanoparticles.Increased cell viability, after short exposure (4 hours) to PLGA/PF68 nanoparticles.

Animal Model:Male Sprague-Dawley rats.Dosage:40 mg/kg (dose of Risperidone, PLGA (75:25) as a drug delivery carrier).Administration:Subcutaneous injection; single.Result:Achieved slow release in vivo: after an initial burst, a sharp drop occurred and the drug levels through day 22 remained in a steady manner while progressing to a decline up to day 45.

poly(lactic-co-glycolic acid)

Others

Other Targets

GABAA

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34346-01-5

166.13

C5H10O6

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL

O=C(O)C(C)OC(CO[H])=O.[x].[y]

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(-20℃)

With Ice Pack

≥ 2 years