PHCCC ( PHCCC )

Catalog No. M17377 CAS No. 179068-02-1

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Datasheet

HNMR

HPLC

MSDS

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Product Name

PHCCC
Note

Research use only, not for human use.
Brief Description

PHCCC is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mGluR2 and mGluR8.
Description

PHCCC is a positive allosteric modulator of mGluR4. PHCCC exhibits proconvulsant action in three models of epileptic seizures in immature rats. PHCCC reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors. PHCCC showed neuroprotection against betaAP- and NMDA-toxicity in mixed cultures of mouse cortical neurons. This neuroprotection was additive to that induced by the highly efficacious mGluR1 antagonist CPCCOEt and was blocked by MSOP, a group-III mGluR antagonist. Our data provide evidence for a novel pharmacological site on mGluR4, which may be used as a target-site for therapeutics.
Synonyms

PHCCC
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

mGluR1
Research Area

Cancer
Indication

——

CAS Number

179068-02-1
Formula Weight

294.31
Molecular Formula

C17H14N2O3
Purity

98%
Solubility

DMSO : ≥ 32 mg/mL; 108.73 mM
SMILES

C12(C(/C(=N/O)/c3ccccc3O1)C2)C(=O)Nc1ccccc1
Chemical Name

(E)-7-(hydroxyimino)-N-phenyl-7,7a-dihydrocyclopropa[b]chromene-1a(1H)-carboxamide

1.Marino MJ et al.Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13668-73.

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