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PGP-4008

CAS No. 365565-02-2

PGP-4008( —— )

Catalog No. M34378 CAS No. 365565-02-2

PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PGP-4008
  • Note
    Research use only, not for human use.
  • Brief Description
    PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.
  • Description
    PGP-4008 is a specific P-glycoprotein (Pgp) inhibitor. PGP-4008 inhibits tumor growth in a murine syngeneic Pgp-mediated multiple agent resistance (MDR) solid tumor model when given in combination with Doxorubicin.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    P-gp
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    365565-02-2
  • Formula Weight
    393.48
  • Molecular Formula
    C26H23N3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (158.84 mM; Ultrasonic (<60°C)
  • SMILES
    O=C(Cc1ccccc1)Nc1c2CCN(Cc3ccccc3)c2nc2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Brian D Lee, et al. Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11;47(6):1413-22.?
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