Cart
sales@molnova.com
PF-956980
CAS No. 1262832-74-5
PF-956980( PF 956980 | PF956980 )
Catalog No. M11099 CAS No. 1262832-74-5
A potent, highly specific JAK3 inhibitor with IC50 of 4 nM; shows only modest inhibition of PKA (6.7 uM) and LCK (10.9 uM) in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NamePF-956980
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, highly specific JAK3 inhibitor with IC50 of 4 nM; shows only modest inhibition of PKA (6.7 uM) and LCK (10.9 uM) in vitro.
-
DescriptionA potent, highly specific JAK3 inhibitor with IC50 of 4 nM; shows only modest inhibition of PKA (6.7 uM) and LCK (10.9 uM) in vitro; selectively downregulates JAK2 and JAK3 mRNA, corresponding to changes observed at the protein level; shows in vivo activity consistent with in vitro enzyme and whole blood assays (39 ng/ml); dose-dependently inhibits the DTH response in mice with EC50 of 5 mg/kg.
-
In Vitro——
-
In Vivo——
-
SynonymsPF 956980 | PF956980
-
PathwayAngiogenesis
-
TargetJAK
-
RecptorJAK
-
Research AreaInflammation/Immunology
-
Indication——
Chemical Information
-
CAS Number1262832-74-5
-
Formula Weight342.44
-
Molecular FormulaC18H26N6O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(N1C[C@H](N(C)C2=C3C(NC=C3)=NC=N2)[C@H](C)CC1)N4CCCC4
-
Chemical Name{(3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-pyrrolidin-1-yl-methanone
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Changelian PS, et al. Blood. 2008 Feb 15;111(4):2155-7.
2. Steele AJ, et al. Blood. 2010 Nov 25;116(22):4569-77.
3. Field SD, et al. ACS Chem Biol. 2017 May 19;12(5):1183-1187.
molnova catalog
related products
-
PRN371
PRN371 is a novel potent, selective JAK3 inhibitor with IC50 of 0.5 nM.
-
Gingerenone A
A dual inhibitor of JAK2 and S6K1 pathways, selectively kills cancer cells while exhibiting minimal toxicity toward normal cells.
-
AZ960
A potent, selective JAK2 inhibitor with Ki of 0.45 nM, IC50 of <3 nM.
