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PF-4878691

CAS No. 532959-63-0

PF-4878691( 3M-852A )

Catalog No. M24509 CAS No. 532959-63-0

PF-4878691 is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-4878691
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-4878691 is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.
  • Description
    PF-4878691 is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.
  • In Vitro
    ——
  • In Vivo
    Animal Model:BALB/c mice , C57bl/6 J mice Dosage:30 mg/kg, 60 mg/kg, 90 mg/kg, 150 mg/kg Administration:Oral gavage (p.o.)Result:Induced dose and time dependant lymphopenia and 2,5,oligoadenylate synthetase (2,5,OAS).Caused cardiovascular changes. Significantly increased TLR7 receptor RNA.
  • Synonyms
    3M-852A
  • Pathway
    Immunology/Inflammation
  • Target
    TLR
  • Recptor
    TLR7
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    532959-63-0
  • Formula Weight
    361.46
  • Molecular Formula
    C17H23N5O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:19.23 mg/mL (53.20 mM; Need ultrasonic)
  • SMILES
    CCc1nc(c(N)nc2ccccc22)c2n1CCCCNS(C)(=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Fidock MD, et al. The innate immune response, clinical outcomes, and ex vivo HCV antiviral efficacy of a TLR7 agonist (PF-4878691). Clin Pharmacol Ther. 2011 Jun;89(6):821-9.
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