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PF-4840154
CAS No. 1332708-14-1
PF-4840154 ( PF-4840154; PF 4840154; PF4840154 )
Catalog No. M17247 CAS No. 1332708-14-1
PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 144 | In Stock |
|
| 5MG | 308 | In Stock |
|
| 10MG | 447 | In Stock |
|
| 25MG | 714 | In Stock |
|
| 50MG | 1017 | In Stock |
|
| 100MG | 1368 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePF-4840154
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NoteResearch use only, not for human use.
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Brief DescriptionPF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively.
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DescriptionPF-4840154 is a non-electrophilic reference agonist of the TrpA1 channel. The TRPA1 channel is considered an attractive pain target based on the fact that TRPA1 knockout mice showed near complete attenuation of pain behaviors in some pre-clinical development models.
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SynonymsPF-4840154; PF 4840154; PF4840154
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PathwayOthers
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TargetOther Targets
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RecptorrTRPA1;hTRPA1
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1332708-14-1
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Formula Weight466.63
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Molecular FormulaC26H38N6O2
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Purity98%
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SolubilityDMSO : 50 mg/mL. 107.15 mM;
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SMILESCC(C)CNc2nc(ncc2C(=O)NCc1ccccc1)N3CCN(CC3)CC4CCCOC4
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Chemical NameN-benzyl-4-(2-methylpropylamino)-2-[4-(oxan-3-ylmethyl)piperazin-1-yl] pyrimidine-5-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ryckmans T,etal.Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel.Bioorg Med Chem Lett. 2011 Aug 15;21(16):4857-9.
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