PF-06952229 ( PF06952229 )

Catalog No. M26371 CAS No. 1801333-55-0

PF-06952229 is an selective and orally active inhibitor of TGFbR1.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
5MG	260	Get Quote
10MG	447	Get Quote
25MG	714	Get Quote
50MG	1017	Get Quote
100MG	1368	Get Quote
500MG	2673	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

PF-06952229
Note

Research use only, not for human use.
Brief Description

PF-06952229 is an selective and orally active inhibitor of TGFbR1.
Description

PF-06952229 is an selective and orally active inhibitor of TGFbR1.(In Vivo):In MCF-7 ER+ HER2-xenograft breast cancer tumor model, PF-06952229 (30 mg/kg; gavage) combines with Palbociclib results in an improved inhibition of pSMAD2 and a significant increase in survival.
Synonyms

PF06952229
Pathway

Others
Target

Other Targets
Recptor

MRP4; OAT1; OAT3
Research Area

——
Indication

——

Chemical Information

CAS Number

1801333-55-0
Formula Weight

458.9
Molecular Formula

C23H24ClFN4O3
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C)c1cnc(cc1Nc1ccncc1C(=O)NC(CO)CO)-c1cc(Cl)ccc1F
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Kamiński T, Micha?owska M, Pawlak D. Aryl hydrocarbon receptor (AhR) and its endogenous agonist - indoxyl sulfate in chronic kidney disease. Postepy Hig Med Dosw (Online). 2017 Jul 30;71(0):624-632. Review.

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