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PF-06952229
CAS No. 1801333-55-0
PF-06952229( PF06952229 )
Catalog No. M26371 CAS No. 1801333-55-0
PF-06952229 is an selective and orally active inhibitor of TGFbR1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 260 | Get Quote |
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| 10MG | 447 | Get Quote |
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| 25MG | 714 | Get Quote |
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| 50MG | 1017 | Get Quote |
|
| 100MG | 1368 | Get Quote |
|
| 500MG | 2673 | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePF-06952229
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NoteResearch use only, not for human use.
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Brief DescriptionPF-06952229 is an selective and orally active inhibitor of TGFbR1.
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DescriptionPF-06952229 is an selective and orally active inhibitor of TGFbR1.(In Vivo):In MCF-7 ER+ HER2-xenograft breast cancer tumor model, PF-06952229 (30 mg/kg; gavage) combines with Palbociclib results in an improved inhibition of pSMAD2 and a significant increase in survival.
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In Vitro——
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In VivoPF-06952229 (oral gavage; 30 mg/kg; twice daily; 21 days) combines with Palbociclib 21 days results in an improved inhibition of pSMAD2 in the MCF7 ER+?xenograft breast cancer tumor model. This combination also leads to a significant increase in survival relative to PF-06952229 monotherapy. Animal Model:MCF-7 ER+?HER2-xenograft breast cancer tumor modelDosage:30 mg/kg Administration:Oral gavage; twice daily; 44 days Result:Resulted in an increase in tumor growth inhibition when combined with Palbociclib.
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SynonymsPF06952229
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PathwayOthers
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TargetOther Targets
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RecptorMRP4| OAT1| OAT3
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Research Area——
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Indication——
Chemical Information
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CAS Number1801333-55-0
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Formula Weight458.92
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Molecular FormulaC23H24ClFN4O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (108.95 mM)
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SMILESCC(C)c1cnc(cc1Nc1ccncc1C(=O)NC(CO)CO)-c1cc(Cl)ccc1F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kamiński T, Micha?owska M, Pawlak D. Aryl hydrocarbon receptor (AhR) and its endogenous agonist - indoxyl sulfate in chronic kidney disease. Postepy Hig Med Dosw (Online). 2017 Jul 30;71(0):624-632. Review.
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