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PF-06928215

CAS No. 2378173-15-8

PF-06928215( —— )

Catalog No. M24095 CAS No. 2378173-15-8

PF-06928215 is an inhibitor of cGAS (cyclic GMP-AMP Synthase) (IC50 of 4.9 μΜ).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-06928215
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-06928215 is an inhibitor of cGAS (cyclic GMP-AMP Synthase) (IC50 of 4.9 μΜ).
  • Description
    PF-06928215 is an inhibitor of cGAS (cyclic GMP-AMP Synthase) (IC50 of 4.9 μΜ).
  • In Vitro
    PF-06928215 displays no activity in cellular cGAS assays measuring dsDNA-induced IFN-beta expression.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    cGAS
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2378173-15-8
  • Formula Weight
    380.4
  • Molecular Formula
    C20H20N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:33.33 mg/mL (87.62 mM; Need ultrasonic)
  • SMILES
    OC1=CC(C2=CC=CC=C2)=NC3=C(C(N[C@H]4CCCC[C@H]4C(O)=O)=O)C=NN13
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hall J, et al. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS One. 2017 Sep 21;12(9):e0184843.
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