PF-06282999

CAS No. 1435467-37-0

PF-06282999 ( PF06282999;PF 06282999 )

Catalog No. M11851 CAS No. 1435467-37-0

A potent, highly selective and irreversible inhibitor of myeloperoxidase (MPO).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 39 In Stock
5MG 65 In Stock
10MG 110 In Stock
25MG 222 In Stock
50MG 357 In Stock
100MG 530 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    PF-06282999
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, highly selective and irreversible inhibitor of myeloperoxidase (MPO).
  • Description
    A potent, highly selective and irreversible inhibitor of myeloperoxidase (MPO) with Kinact/KI of 116000 M-1s-1; displays high selectivity for MPO over TPO and cytochrome P450 isoforms; shows excellent pharmacological and pharmacokinetic profile; orally active. Thrombosis Phase 1 Clinical
  • Synonyms
    PF06282999;PF 06282999
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Myeloperoxidase
  • Research Area
    Cardiovascular Disease
  • Indication
    Thrombosis

Chemical Information

  • CAS Number
    1435467-37-0
  • Formula Weight
    325.77
  • Molecular Formula
    C13H12ClN3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 32 mg/mL
  • SMILES
    O=C(N)CN(C(N1)=S)C(C2=CC(Cl)=CC=C2OC)=CC1=O
  • Chemical Name
    1(2H)-Pyrimidineacetamide, 6-(5-chloro-2-methoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ruggeri RB, et al. J Med Chem. 2015 Nov 12;58(21):8513-28.
2. Dong JQ, et al. Drug Metab Dispos. 2016 Feb;44(2):209-19.
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