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PF-06282999
CAS No. 1435467-37-0
PF-06282999 ( PF06282999;PF 06282999 )
Catalog No. M11851 CAS No. 1435467-37-0
A potent, highly selective and irreversible inhibitor of myeloperoxidase (MPO).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 39 | In Stock |
|
| 5MG | 65 | In Stock |
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| 10MG | 110 | In Stock |
|
| 25MG | 222 | In Stock |
|
| 50MG | 357 | In Stock |
|
| 100MG | 530 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePF-06282999
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, highly selective and irreversible inhibitor of myeloperoxidase (MPO).
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DescriptionA potent, highly selective and irreversible inhibitor of myeloperoxidase (MPO) with Kinact/KI of 116000 M-1s-1; displays high selectivity for MPO over TPO and cytochrome P450 isoforms; shows excellent pharmacological and pharmacokinetic profile; orally active. Thrombosis Phase 1 Clinical
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SynonymsPF06282999;PF 06282999
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PathwayOthers
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TargetOther Targets
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RecptorMyeloperoxidase
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Research AreaCardiovascular Disease
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IndicationThrombosis
Chemical Information
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CAS Number1435467-37-0
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Formula Weight325.77
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Molecular FormulaC13H12ClN3O3S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 32 mg/mL
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SMILESO=C(N)CN(C(N1)=S)C(C2=CC(Cl)=CC=C2OC)=CC1=O
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Chemical Name1(2H)-Pyrimidineacetamide, 6-(5-chloro-2-methoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ruggeri RB, et al. J Med Chem. 2015 Nov 12;58(21):8513-28.
2. Dong JQ, et al. Drug Metab Dispos. 2016 Feb;44(2):209-19.
2. Dong JQ, et al. Drug Metab Dispos. 2016 Feb;44(2):209-19.
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