PF-06282999 ( PF06282999;PF 06282999 )

Catalog No. M11851 CAS No. 1435467-37-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PF-06282999
Note

Research use only, not for human use.
Brief Description

A potent, highly selective and irreversible inhibitor of myeloperoxidase (MPO).
Description

A potent, highly selective and irreversible inhibitor of myeloperoxidase (MPO) with Kinact/KI of 116000 M-1s-1; displays high selectivity for MPO over TPO and cytochrome P450 isoforms; shows excellent pharmacological and pharmacokinetic profile; orally active. Thrombosis Phase 1 Clinical
Synonyms

PF06282999;PF 06282999
Pathway

Others
Target

Other Targets
Recptor

Myeloperoxidase
Research Area

Cardiovascular Disease
Indication

Thrombosis

CAS Number

1435467-37-0
Formula Weight

325.77
Molecular Formula

C13H12ClN3O3S
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 32 mg/mL
SMILES

O=C(N)CN(C(N1)=S)C(C2=CC(Cl)=CC=C2OC)=CC1=O
Chemical Name

1(2H)-Pyrimidineacetamide, 6-(5-chloro-2-methoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-

1. Ruggeri RB, et al. J Med Chem. 2015 Nov 12;58(21):8513-28.
2. Dong JQ, et al. Drug Metab Dispos. 2016 Feb;44(2):209-19.

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