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PF-04895162
CAS No. ——
PF-04895162( ICA-105665 | PF 04895162 | ICA105665 | PF 4895162 )
Catalog No. M16958 CAS No. ——
PF-04895162 (ICA-105665, PF 4895162) is an orally available agonist of neuronal Kv7 potassium channel, opens Kv7.2/7.3 and Kv7.3/7.5 potassium channels.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePF-04895162
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NoteResearch use only, not for human use.
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Brief DescriptionPF-04895162 (ICA-105665, PF 4895162) is an orally available agonist of neuronal Kv7 potassium channel, opens Kv7.2/7.3 and Kv7.3/7.5 potassium channels.
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DescriptionPF-04895162 (ICA-105665, PF 4895162) is an orally available agonist of neuronal Kv7 potassium channel, opens Kv7.2/7.3 and Kv7.3/7.5 potassium channels, also known as KCNQ2/3 and KCNQ3/5 channels; ICA-105665 has demonstrated broad spectrum antiseizure activity in multiple animal models including maximal electroshock, 6 Hz seizures, pentylenetetrazole, and electrical kindling at doses from <1 to 5 mg/kg.Epilepsy Phase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsICA-105665 | PF 04895162 | ICA105665 | PF 4895162
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight355.345
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Molecular FormulaC19H15F2N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameN-(2-cyclopropyl-7-fluoro-4-oxoquinazolin-3(4H)-yl)-2-(4-fluorophenyl)ethanamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kasteleijn-Nolst Trenité DG, et al. Epilepsia. 2013 Aug;54(8):1437-43.
2. Aleo MD, et al. Pharmacol Res Perspect. 2019 Feb;7(1):e00467.
3. Bialer M, et al. Epilepsy Res. 2013 Jan;103(1):2-30.
4. Roeloffs R, et al. J Pharmacol Exp Ther. 2008 Sep;326(3):818-28.
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