PF-03814735 ( —— )

Catalog No. M17679 CAS No. 942487-16-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PF-03814735
Note

Research use only, not for human use.
Brief Description

PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.
Description

PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Aurora A; Aurora B;FLT1 ;FAK; TrkA
Research Area

Cancer
Indication

——

CAS Number

942487-16-3
Formula Weight

474.48
Molecular Formula

C23H25F3N6O2
Purity

98%
Solubility

DMSO : ≥ 47 mg/mL; 99.06 mM
SMILES

CC(=O)NCC(=O)N1[C@H]2CC[C@@H]1C3=C2C=CC(=C3)NC4=NC=C(C(=N4)NC5CCC5)C(F)(F)F
Chemical Name

——