Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Histamine Receptor - PF-03654764

PF-03654764

CAS No. 935840-35-0

PF-03654764 ( PF 3654764 )

Catalog No. M16695 CAS No. 935840-35-0

PF-03654764 (PF 3654764) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 1.4 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 1137 Get Quote
25MG 1945 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    PF-03654764
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-03654764 (PF 3654764) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 1.4 nM.
  • Description
    PF-03654764 (PF 3654764) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 1.4 nM; displays >1000-fold selectivity versus H1, H2, H4 and other GPCRs (IC50>10 uM); possesses optimal pharmacological and pharmacokinetic profiles, shows potential in allergen-induced nasal symptoms. Allergy Phase 2 Discontinued
  • Synonyms
    PF 3654764
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    Histamine Receptor
  • Research Area
    Inflammation/Immunology
  • Indication
    Allergy

Chemical Information

  • CAS Number
    935840-35-0
  • Formula Weight
    322.45
  • Molecular Formula
    C18H24F2N2O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)CNC(=O)C1CC(C1)(C2=CC(=C(C=C2)CN3CCCC3)F)F
  • Chemical Name
    Trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wager TT, et al. J Med Chem. 2011 Nov 10;54(21):7602-20.
2. North ML, et al. Allergy Asthma Clin Immunol. 2014 Jul 3;10(1):33.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Diphenhydramine

    Diphenhydramine, a first-generation antihistamine possessing antiemetic, antitussive, anticholinergic, and sedative properties, is mainly used in the treatment of allergies.

  • Astemizole

    Astemizole (R 43512), a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM.

  • Cetirizine dihydroch...

    A second-generation antihistamine that acts as a selective H1 receptor antagonist.

Sign In Join Free