PF-03654746
CAS No. 935840-31-6
PF-03654746 ( PF 3654746 )
Catalog No. M16694 CAS No. 935840-31-6
PF-03654746 (PF 3654746) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 2.3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 393 | Get Quote |
|
10MG | 590 | Get Quote |
|
25MG | 1060 | Get Quote |
|
50MG | 1591 | Get Quote |
|
100MG | 2387 | Get Quote |
|
200MG | 3580 | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePF-03654746
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NoteResearch use only, not for human use.
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Brief DescriptionPF-03654746 (PF 3654746) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 2.3 nM.
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DescriptionPF-03654746 (PF 3654746) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 2.3 nM; dislaplays >1000-fold selectivity versus H1, H2, H4 and other GPCRs (IC50>10 uM); possesses optimal pharmacological and pharmacokinetic profiles, shows potential in allergen-induced nasal symptoms.Allergy Phase 2 Discontinued
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SynonymsPF 3654746
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PathwayGPCR/G Protein
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TargetHistamine Receptor
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RecptorHistamine Receptor
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Research AreaInflammation/Immunology
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IndicationAllergy
Chemical Information
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CAS Number935840-31-6
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Formula Weight322.40
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Molecular FormulaC18H24F2N2O
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C([C@H]1C[C@@](C2=CC=C(CN3CCCC3)C(F)=C2)(F)C1)NCC
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Chemical NameTrans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wager TT, et al. J Med Chem. 2011 Nov 10;54(21):7602-20.
2. Stokes JR, et al. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2.
3. Gallezot JD, et al. J Cereb Blood Flow Metab. 2017 Mar;37(3):1095-1107.
2. Stokes JR, et al. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2.
3. Gallezot JD, et al. J Cereb Blood Flow Metab. 2017 Mar;37(3):1095-1107.
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