PF-00835231( —— )

Catalog No. M28699 CAS No. 870153-29-0

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Datasheet

HNMR

HPLC

MSDS

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Product Name

PF-00835231
Note

Research use only, not for human use.
Brief Description

PF-00835231 is a CoV-2 cysteine 3C-like protease (3CLpro) inhibitor, with IC50s of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CLpro, respectively.PF-00835231 is the active compound of the first anti-3CLpro regimen in clinical trials.
Description

PF-00835231 is a CoV-2 cysteine 3C-like protease (3CLpro) inhibitor, with IC50s of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CLpro, respectively.PF-00835231 is the active compound of the first anti-3CLpro regimen in clinical trials.
In Vitro

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In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

glucocerebrosidase
Research Area

——
Indication

——

CAS Number

870153-29-0
Formula Weight

944.06
Molecular Formula

C48H63N8O12
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (529.07 mM)
SMILES

CC(C)C[C@@H](C(N[C@@H](C[C@H](CCN1)C1=O)C(CO)=O)=O)NC(c1cc(c(OC)ccc2)c2[nH]1)=OCC(C)C[C@@H](C(N[C@@H](C[C@H](CCN1)C1=O)C(CO)=O)=O)NC(c1cc(c(OC)ccc2)c2[nH]1)=O
Chemical Name

——

1.Rogers S, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. 2012 Mar 27 [updated 2013 Mar 7].

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