PEN-221
CAS No. 1853254-97-3
PEN-221 ( )
Catalog No. M30502 CAS No. 1853254-97-3
PEN-221 is a Somatostatin receptor 2 (SSTR2)-targeting cytotoxic conjugate with an IC50 of 10 nM. PEN-221 is a conjugate consisting of microtubule-targeting agent DM1 linked to the C-terminal side chain of Tyr3-octreotate.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
100MG | Get Quote | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
Biological Information
-
Product NamePEN-221
-
NoteResearch use only, not for human use.
-
Brief DescriptionPEN-221 is a Somatostatin receptor 2 (SSTR2)-targeting cytotoxic conjugate with an IC50 of 10 nM. PEN-221 is a conjugate consisting of microtubule-targeting agent DM1 linked to the C-terminal side chain of Tyr3-octreotate.
-
DescriptionPEN-221 is a Somatostatin receptor 2 (SSTR2)-targeting cytotoxic conjugate with an IC50 of 10 nM. PEN-221 is a conjugate consisting of microtubule-targeting agent DM1 linked to the C-terminal side chain of Tyr3-octreotate.
-
Synonyms
-
PathwayOthers
-
TargetOther Targets
-
RecptorIC50: 10 nM (SSTR2)
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1853254-97-3
-
Formula Weight1786.6
-
Molecular FormulaC83H109ClN14O20S4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
White BH, et al. Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo. J Med Chem. 2019 Mar 14;62(5):2708-2719.
molnova catalog
related products
-
Lats-IN-1
Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.
-
1-Methyluric acid
1-Methyluric acid acts on the urinary bladder mucosa and increases blood glucose, triglyceride, insulin, and cholesterol levels.
-
Isomogroside V
Isomogroside V is a sweetener extracted from Siraitia grosvenorii that is approximately 500 times sweeter than 0.5% (w/v) sucrose.