PEN-221

CAS No. 1853254-97-3

PEN-221 ( )

Catalog No. M30502 CAS No. 1853254-97-3

PEN-221 is a Somatostatin receptor 2 (SSTR2)-targeting cytotoxic conjugate with an IC50 of 10 nM. PEN-221 is a conjugate consisting of microtubule-targeting agent DM1 linked to the C-terminal side chain of Tyr3-octreotate.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote

Biological Information

  • Product Name
    PEN-221
  • Note
    Research use only, not for human use.
  • Brief Description
    PEN-221 is a Somatostatin receptor 2 (SSTR2)-targeting cytotoxic conjugate with an IC50 of 10 nM. PEN-221 is a conjugate consisting of microtubule-targeting agent DM1 linked to the C-terminal side chain of Tyr3-octreotate.
  • Description
    PEN-221 is a Somatostatin receptor 2 (SSTR2)-targeting cytotoxic conjugate with an IC50 of 10 nM. PEN-221 is a conjugate consisting of microtubule-targeting agent DM1 linked to the C-terminal side chain of Tyr3-octreotate.
  • Synonyms
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    IC50: 10 nM (SSTR2)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1853254-97-3
  • Formula Weight
    1786.6
  • Molecular Formula
    C83H109ClN14O20S4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

White BH, et al. Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo. J Med Chem. 2019 Mar 14;62(5):2708-2719.
molnova catalog
related products
  • Lats-IN-1

    Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.

  • 1-Methyluric acid

    1-Methyluric acid acts on the urinary bladder mucosa and increases blood glucose, triglyceride, insulin, and cholesterol levels.

  • Isomogroside V

    Isomogroside V is a sweetener extracted from Siraitia grosvenorii that is approximately 500 times sweeter than 0.5% (w/v) sucrose.