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PDE9-IN-1

CAS No. 2305087-92-5

PDE9-IN-1( —— )

Catalog No. M26362 CAS No. 2305087-92-5

PDE9-IN-1 is a potent, selective, and orally bioavailable Inhibitor of phosphodiesterase-9A (PDE9A)(IC50 of 8.7 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PDE9-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    PDE9-IN-1 is a potent, selective, and orally bioavailable Inhibitor of phosphodiesterase-9A (PDE9A)(IC50 of 8.7 nM).
  • Description
    PDE9-IN-1 is a potent, selective, and orally bioavailable Inhibitor of phosphodiesterase-9A (PDE9A)(IC50 of 8.7 nM).(In Vivo):In the Unilateral common carotid artery occlusion (UCCAO) mouse model, PDE9-IN-1 (2.5-5.0 mg/kg; orally) significantly reduces the day 6 escape latency time, increases the frequency of platform area crossings, and recoveres learning and memory function. High dose group possibly improved the escape latency time of mice.
  • In Vitro
    PDE9-IN-1 is excellent selectivity across PDE families.
  • In Vivo
    PDE9-IN-1 (2.5 and 5.0 mg/kg; Oral administration; daily for 21 days) effectively recovers learning and memory function. Animal Model:Unilateral common carotid artery occlusion (UCCAO) mouse model Dosage:2.5 and 5.0 mg/kg Administration:Oral administration; daily for 21 days Result:Significantly reduced the day 6 escape latency time and increased the frequency of platform area crossings, and recovered learning and memory function. High dose group possibly improved the escape latency time of mice.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    NMDA receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2305087-92-5
  • Formula Weight
    362.409
  • Molecular Formula
    C17H23FN6O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (275.94 mM)
  • SMILES
    C[C@@H](Nc1nc2n(ncc2c(=O)[nH]1)C1CCCC1)C(=O)N1CC[C@H](F)C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lozovaya N, Gataullina S, et al. Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model. Nat Commun. 2014 Aug 1;5:4563.
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