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PD-150606

CAS No. 179528-45-1

PD-150606( PD 150606 | PD150606 )

Catalog No. M12710 CAS No. 179528-45-1

A potent and selective calpain inhibitor with Ki of 0.21 uM/0.37 uM for u-calpain/m-calpain, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PD-150606
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective calpain inhibitor with Ki of 0.21 uM/0.37 uM for u-calpain/m-calpain, respectively.
  • Description
    A potent and selective calpain inhibitor with Ki of 0.21 uM/0.37 uM for u-calpain/m-calpain, respectively; shows no inhibition for other proteases (cathepin B, papain, trypsin and thermolysin (Ki> 500 uM); attenuate shypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PD 150606 | PD150606
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Proteasome
  • Recptor
    Proteasome
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    179528-45-1
  • Formula Weight
    306.1201
  • Molecular Formula
    C9H7IO2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 28 mg/mL
  • SMILES
    O=C(O)/C(S)=C/C1=CC=C(I)C=C1
  • Chemical Name
    2-Propenoic acid, 3-(4-iodophenyl)-2-mercapto-, (2Z)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang KK, et al. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92. 2. Niapour M, et al. J Biol Chem. 2008 Aug 1;283(31):21371-81. 3. Waters SL, et al. J Pharmacol Exp Ther. 1997 Dec;283(3):1177-84.
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