PCI-27483
CAS No. 871266-63-6
PCI-27483 ( PCI27483; PCI-27483; PCI 27483 )
Catalog No. M17634 CAS No. 871266-63-6
PCI 27483 is an activated coagulation factor VIIa inhibitor with antithrombotic effects in a baboon model of arterial thrombosis.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 71 | In Stock |
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10MG | 120 | In Stock |
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25MG | 203 | In Stock |
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50MG | 306 | In Stock |
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100MG | Get Quote | In Stock |
|
200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NamePCI-27483
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NoteResearch use only, not for human use.
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Brief DescriptionPCI 27483 is an activated coagulation factor VIIa inhibitor with antithrombotic effects in a baboon model of arterial thrombosis.
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DescriptionPCI-27483 is a reversible small-molecule inhibitor of activated factor VII (factor VIIa) with potential antineoplastic and antithrombotic activities. FVII, a serine protease, becomes activated (FVIIa) upon binding with TF forming the FVIIa/TF complex, which induces intracellular signaling pathways by activating protease activated receptor 2 (PAR-2). Upon subcutaneous administration, factor VIIa inhibitor PCI-27483 selectively inhibits factor FVIIa in the VIIa/TF complex, which may prevent PAR-2 activation and PAR2-mediated signal transduction pathways, thereby inhibiting tumor cell proliferation, angiogenesis, and metastasis of TF-overexpressing tumor cells.
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SynonymsPCI27483; PCI-27483; PCI 27483
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PathwayAngiogenesis
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TargetCDK
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RecptorCoagulation factor
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Research Area——
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Indication——
Chemical Information
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CAS Number871266-63-6
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Formula Weight596.57
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Molecular FormulaC26H24N6O9S
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Purity98%
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Solubility——
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SMILESc1cc2c(cc1C(=N)N)[nH]c(c1cc(cc(c1O)c1c(ccc(c1)S(=O)(=O)N)O)CC(=O)NC(CC(=O)O)C(=O)O)n2
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Chemical Name(S)-2-(2-(5-(5-carbamimidoyl-1H-benzo[d]imidazol-2-yl)-2',6-dihydroxy-5'-sulfamoyl-[1,1'-biphenyl]-3-yl)acetamido)succinic acid.
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gómez-Outes, A, et al. New parenteral anticoagulants in development. Ther. Adv. Cardiovasc. Disc. 5(1), 33-59 (2011).
molnova catalog
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