PCI-27483

CAS No. 871266-63-6

PCI-27483 ( PCI27483; PCI-27483; PCI 27483 )

Catalog No. M17634 CAS No. 871266-63-6

PCI 27483 is an activated coagulation factor VIIa inhibitor with antithrombotic effects in a baboon model of arterial thrombosis.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 71 In Stock
10MG 120 In Stock
25MG 203 In Stock
50MG 306 In Stock
100MG Get Quote In Stock
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500MG Get Quote In Stock
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Biological Information

  • Product Name
    PCI-27483
  • Note
    Research use only, not for human use.
  • Brief Description
    PCI 27483 is an activated coagulation factor VIIa inhibitor with antithrombotic effects in a baboon model of arterial thrombosis.
  • Description
    PCI-27483 is a reversible small-molecule inhibitor of activated factor VII (factor VIIa) with potential antineoplastic and antithrombotic activities. FVII, a serine protease, becomes activated (FVIIa) upon binding with TF forming the FVIIa/TF complex, which induces intracellular signaling pathways by activating protease activated receptor 2 (PAR-2). Upon subcutaneous administration, factor VIIa inhibitor PCI-27483 selectively inhibits factor FVIIa in the VIIa/TF complex, which may prevent PAR-2 activation and PAR2-mediated signal transduction pathways, thereby inhibiting tumor cell proliferation, angiogenesis, and metastasis of TF-overexpressing tumor cells.
  • Synonyms
    PCI27483; PCI-27483; PCI 27483
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    Coagulation factor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    871266-63-6
  • Formula Weight
    596.57
  • Molecular Formula
    C26H24N6O9S
  • Purity
    98%
  • Solubility
    ——
  • SMILES
    c1cc2c(cc1C(=N)N)[nH]c(c1cc(cc(c1O)c1c(ccc(c1)S(=O)(=O)N)O)CC(=O)NC(CC(=O)O)C(=O)O)n2
  • Chemical Name
    (S)-2-(2-(5-(5-carbamimidoyl-1H-benzo[d]imidazol-2-yl)-2',6-dihydroxy-5'-sulfamoyl-[1,1'-biphenyl]-3-yl)acetamido)succinic acid.

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gómez-Outes, A, et al. New parenteral anticoagulants in development. Ther. Adv. Cardiovasc. Disc. 5(1), 33-59 (2011).
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