PAT-1251 ( PAT 1251;PAT1251 )

Catalog No. M13132 CAS No. 2007885-39-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

PAT-1251
Note

Research use only, not for human use.
Brief Description

PAT-1251 (PAT 1251, PAT1251) is apotent, selective and orally bioavailable lysyl oxidase-like 2 (LOXL2) inhibitor with IC50 of 0.71 uM in human whole blood assays.
Description

PAT-1251 (PAT 1251, PAT1251) is apotent, selective and orally bioavailable lysyl oxidase-like 2 (LOXL2) inhibitor with IC50 of 0.71 uM in human whole blood assays, with high selectivity over LOX (400-fold) and other amine oxidases; exhibits efficacy in mouse bleomycin lung fibrosis model.Fibrosis Phase 1 Clinical
Synonyms

PAT 1251;PAT1251
Pathway

Others
Target

Other Targets
Recptor

Other Targets
Research Area

Other Indications
Indication

Fibrosis

CAS Number

2007885-39-2
Formula Weight

399.35
Molecular Formula

C18H17F4N3O3
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 130 mg/mL 325.54 mM
SMILES

O=C(C1=CC=CC(OC2=NC(C(F)(F)F)=CC(CN)=C2)=C1)N3C[C@@H](F)[C@H](O)C3
Chemical Name

(3-((4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)((3R,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl)methanone

1. Rowbottom MW, et al. J Med Chem. 2017 May 25;60(10):4403-4423.

Calculator

molnova catalog