P516-0475 ( P516-0475; P5160475; P516 0475 )

Catalog No. M11475 CAS No. 1359627-33-0

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Product Name

P516-0475
Note

Research use only, not for human use.
Brief Description

P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO (IC50=10 uM).
Description

P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO (IC50=10 uM); specifically induces expression of Rgg2/3-regulated genes in the presence of SHP pheromones at concentrations lower than typically required for QS induction; P516-0475 directly inhibits recombinant PepO in vitro as an uncompetitive inhibitor, induces QS by stabilizing SHP pheromones in culture.
Synonyms

P516-0475; P5160475; P516 0475
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

CAS Number

1359627-33-0
Formula Weight

315.33
Molecular Formula

C15H17N5O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=C2N(N=N1)C3=C(C=C(C)C=C3)NC2=O)NCCCOC
Chemical Name

N-(3-methoxypropyl)-7-methyl-4-oxo-4,5-dihydro-[1,2,3]triazolo[1,5-a]quinoxaline-3-carboxamide

1. Pérez Morales TG, et al. J Biol Chem. 2018 Jan 19;293(3):931-940.

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