P005091

Research use only, not for human use.

P005091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.

P005091 is a potent and selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 μ M). P005091 induces elevated p53 and apoptosis in cancer cell lines and displays antiangiogenic activity in vivo . The deubiquitylating enzyme USP7 (HAUSP) sits at a critical node regulating the activities of numerous proteins broadly characterized as tumor suppressors, DNA repair proteins, immune responders, viral proteins, and epigenetic modulators. Aberrant USP7 activity may promote oncogenesis and viral disease making it a compelling target for therapeutic intervention.

P005091; P-005091; P 005091;P 5091

Others

Other Targets

USP7

Cancer

——

882257-11-6

348.21

C12H7Cl2NO3S2

98%

DMSO : 50 mg/mL 143.59 mM; H2O : < 0.1 mg/mL

CC(=O)c1cc(c(Sc2cccc(Cl)c2Cl)s1)[N+](=O)[O-]

1-(5-((2,3-dichlorophenyl)thio)-4-nitrothiophen-2-yl)ethanone

(-20℃)

With Ice Pack

≥ 2 years