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Oxythiamine
CAS No. 136-16-3
Oxythiamine( —— )
Catalog No. M33051 CAS No. 136-16-3
Oxythiamine (Hydroxythiamin) is an antivitamin of thiamine and a transketolase (TK) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 28 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameOxythiamine
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NoteResearch use only, not for human use.
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Brief DescriptionOxythiamine (Hydroxythiamin) is an antivitamin of thiamine and a transketolase (TK) inhibitor.
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DescriptionOxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine inhibits cancer cell apoptosis and inhibits cell proliferation.
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In VitroCell Viability Assay Cell Line:MIA PaCa-2 cells Concentration:0-40 μM Incubation Time:2 days Result:Inhibited cell viability with an IC50 of 14.95 μM.Western Blot Analysis Cell Line:MIA PaCa-2 cells Concentration:0, 5, 50, 500 μM Incubation Time:48 h Result:Inhibited 14-3-3 protein beta/alpha expression, and increased alpha-enolase.
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In VivoAnimal Model:Ehrlich's ascites tumor hosting miceDosage:100-500 mg/kg Administration:i.p., 4 days Result:Inhibited tumor growth by 43% at 300 mg/kg and 84% at 500 mg/kg.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorTransketolase | Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number136-16-3
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Formula Weight266.34
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Molecular FormulaC12H16N3O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 51.67 mg/mL (194.00 mM; Ultrasonic )
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SMILESO=C1NC(=NC=C1C[N+]2=CSC(=C2C)CCO)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang J, et al. Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells. Exp Hematol Oncol. 2013 Jul 27;2:18. ?
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