Oxysanguinarine

Research use only, not for human use.

Oxysanguinarine possesses antiplatelet aggregation activity, it has potential inhibitory properties against the dengue virus.

Oxysanguinarine possesses antiplatelet aggregation activity, it has potential inhibitory properties against the dengue virus.(In Vitro):A total of 2750 phytochemicals from different medicinal plants were selected for this study. These plants grow naturally in the climate of Pakistan and India and have been used for the treatment of various pathologies in humans for a long-time. The ADMET studies, molecular docking and density functional theory (DFT) based analysis was carried out to determine the potential inhibitory properties of these phytochemicals. The ADMET analysis and docking results revealed nine phytochemicals, i.e. Silymarin, Flavobion, Derrisin, Isosilybin, Mundulinol, Silydianin, Isopomiferin, Narlumicine and Oxysanguinarine to have potential inhibitory properties against DENV and can be considered for additional in vitro and in vivo studies to assess their inhibitory effects against DENV replication. They exhibited binding affinity ≥ -8 kcal/mol against DENV4-NS4B. Furthermore, DFT-based analysis revealed high reactivity for these nine phytochemicals in the binding pocket of DENV4-NS4B, based on ELUMO, EHOMO and band energy gap.

8-Oxosanguinarine; Hydroxysanguinarine

Microbiology/Virology

Parasite

Parasite

——

——

548-30-1

347.3

C20H13NO5

>98% (HPLC)

——

Cn1c2c(ccc3cc4OCOc4cc23)c2ccc3OCOc3c2c1=O

——

(-20℃)

With Ice Pack

≥ 2 years