Oxindole

CAS No. 59-48-3

Oxindole ( Indolin-2-one )

Catalog No. M22658 CAS No. 59-48-3

Oxindole is an aromatic heterocyclic building block.?2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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500MG 84 In Stock
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Biological Information

  • Product Name
    Oxindole
  • Note
    Research use only, not for human use.
  • Brief Description
    Oxindole is an aromatic heterocyclic building block.?2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.
  • Description
    Oxindole is an aromatic heterocyclic building block.?2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.We synthesized a series of novel 5-24 derivatives of Oxindole. METHODS AND RESULTS: The synthesis started from 5-chloroOxindole, which was condensed with methyl 4-carboxybezoate and result in the formation of benzolyester derivatives of Oxindole which was then treated with hydrazine hydrate. The Oxindole benzoylhydrazide was treated with aryl acetophenones and aldehydes to get target compounds 5-24. The synthesized compounds were evaluated for urease inhibition; the compound 5 (IC50 = 13.00 ± 0.35 μM) and 11 (IC50 = 19.20 ± 0.50 μM) showed potent activity as compared to the standard drug thiourea (IC50 = 21.00 ± 0.01 μM). Other compounds showed moderate to weak activity.
  • Synonyms
    Indolin-2-one
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    59-48-3
  • Formula Weight
    133.2
  • Molecular Formula
    C8H7NO
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:97 mg/mL (728.23 mM; Need ultrasonic)
  • SMILES
    O=C1Cc2ccccc2N1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Synthesis of novel derivatives of oxindole, their urease inhibition and molecular docking studies. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3285-9.
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