
Oxaceprol
CAS No. 33996-33-7
Oxaceprol( N-Acetyl-L-hydroxyproline )
Catalog No. M21329 CAS No. 33996-33-7
Oxaceprol is an established therapeutic agent for osteoarthritis.
Purity : >98% (HPLC)






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Biological Information
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Product NameOxaceprol
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NoteResearch use only, not for human use.
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Brief DescriptionOxaceprol is an established therapeutic agent for osteoarthritis.
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DescriptionOxaceprol is an established therapeutic agent for osteoarthritis.(In Vitro):Oxaceprol, at 6 mg/kg/day for 7 days, significantly reduces both the surface area and wet weight of cotton pellet granulomas, being slightly less effective than indomethacin, 3 mg/kg.Oxaceprol (6–54 mg/kg/day) given therapeutically had no effect on the primary paw oedema response, but inhibits secondary lesions in the ears and tail.Oxaceprol does not inhibit the synthesis of prostaglandins in vitro, but markedly inhibits neutrophil infiltration into the joints of rats with adjuvant arthritis.
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In Vitro——
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In VivoOxaceprol, at 6 mg/kg/day for 7 days, significantly reduces both the surface area and wet weight of cotton pellet granulomas, being slightly less effective than indomethacin, 3 mg/kg.Oxaceprol (6–54 mg/kg/day) given therapeutically had no effect on the primary paw oedema response, but inhibits secondary lesions in the ears and tail.Oxaceprol does not inhibit the synthesis of prostaglandins in vitro, but markedly inhibits neutrophil infiltration into the joints of rats with adjuvant arthritis. Animal Model:Male Sprague-Dawley rats.Dosage:18, 50 or 150 mg/kg.Administration:Gavage daily for 15 days.Result:Produced comparable inhibition of hyperalgesia to that produced by indomethacin.
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SynonymsN-Acetyl-L-hydroxyproline
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number33996-33-7
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Formula Weight173.17
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Molecular FormulaC7H11NO4
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Purity>98% (HPLC)
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SolubilityDMSO:1 mg/mL (577.47 mM)
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SMILESCC(=O)N1C[C@@H](C[C@H]1C(=O)O)O
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Chemical Name(2S4R)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ionac M Parnham M J Plauchithiu M et al. OXACEPROL AN ATYPICAL INHIBITOR OF INFLAMMATION AND JOINT DAMAGE[J]. pharmacological research 1996 33(6):367-373.
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