
Ormetoprim
CAS No. 6981-18-6
Ormetoprim( Ro 5-9754 | Ro-5-9754 | Ro5-9754 )
Catalog No. M27313 CAS No. 6981-18-6
Ormetoprim, an antibiotic approved for use in the United States, is used to prevent the spread of disease in freshwater aquaculture.
Purity : >98% (HPLC)






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2MG | 51 | In Stock |
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10MG | 124 | In Stock |
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25MG | 210 | In Stock |
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50MG | 311 | In Stock |
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100MG | 462 | In Stock |
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Biological Information
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Product NameOrmetoprim
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NoteResearch use only, not for human use.
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Brief DescriptionOrmetoprim, an antibiotic approved for use in the United States, is used to prevent the spread of disease in freshwater aquaculture.
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DescriptionOrmetoprim, an antibiotic approved for use in the United States, is used to prevent the spread of disease in freshwater aquaculture.(In Vivo):Ormetoprim (8.3 mg/kg; i.p.) exhibits absorption half-life (5.4 h), elimination half-life (7.5 h) and Cmax (1.2±0.2 μg/mL).Ormetoprim (8.3 mg/kg; p.o.) exhibits absorption half-life (3.9 h), elimination half-life (3.9 h), Cmax (1.6±0.4 μg/mL) and oral availability (78.5%) relative to intraperitoneal administration.
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In Vitro——
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In VivoOrmetoprim (8.3 mg/kg; i.p.) exhibits absorption half-life (5.4 h), elimination half-life (7.5 h) and Cmax (1.2±0.2 μg/mL).Ormetoprim (8.3 mg/kg; p.o.) exhibits absorption half-life (3.9 h), elimination half-life (3.9 h), Cmax (1.6±0.4 μg/mL) and oral availability (78.5%) relative to intraperitoneal administration. Animal Model:Hybrid striped bass (565-805 g)Dosage:50 mg/kg Sulfadimethoxine and Ormetoprim in a 5:1 ratio (Pharmacokinetic Analysis)Administration:I.p. and p.o. administration Result:I.p.: t1/2(elim)=7.5 h; t1/2(abs)=5.4 h; Cmax=1.2 μg/mL.P.o.: t1/2(elim)=3.9 h; t1/2(abs)=3.9 h; Cmax=1.6 μg/mL; F=78.5%.
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SynonymsRo 5-9754 | Ro-5-9754 | Ro5-9754
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PathwayMicrobiology/Virology
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TargetAntibiotic
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Recptorpapain-like protease (PLpro)
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Research Area——
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Indication——
Chemical Information
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CAS Number6981-18-6
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Formula Weight274.324
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Molecular FormulaC14H18N4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (91.13 mM)
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SMILESCOc1cc(C)c(Cc2cnc(N)nc2N)cc1OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ghosh AK, Takayama J, Aubin Y, Ratia K, Chaudhuri R, Baez Y, Sleeman K, Coughlin M, Nichols DB, Mulhearn DC, Prabhakar BS, Baker SC, Johnson ME, Mesecar AD. Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome-coronavirus papain-like protease. J Med Chem. 2009 Aug 27;52(16):5228-40. doi: 10.1021/jm900611t. PMID: 19645480; PMCID: PMC3148848.
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