Optovin ( Optovin )

Catalog No. M18460 CAS No. 348575-88-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Optovin
Note

Research use only, not for human use.
Brief Description

Optovin is a TRPA1 activator, which is reversibly photoactivated.
Description

Optovin is a photoactive TRPA1 activator. Optovin activates human TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues. In animals with severed spinal cords, optovin treatment enables control of motor activity in the paralyzed extremities by localized illumination. These studies identify a light-based strategy for controlling endogenous TRPA1 receptors in vivo, with potential clinical and research applications in nontransgenic animals, including humans.
Synonyms

Optovin
Pathway

Membrane Transporter/Ion Channel
Target

Sodium Channel
Recptor

TRPA1
Research Area

Others-Field
Indication

——

CAS Number

348575-88-2
Formula Weight

315.41
Molecular Formula

C15H13N3OS2
Purity

98%
Solubility

DMSO : ≥ 37 mg/mL; 117.31 mM
SMILES

S1C(=S)NC(=O)/C/1=C\c1c(n(c(c1)C)c1cnccc1)C
Chemical Name

(Z)-5-((2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl)methylene)-2-thioxothiazolidin-4-one

1. Kokel D, et al. Nat Chem Biol. 2013, 9(4), 257-263.

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