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Ononetin

CAS No. 487-49-0

Ononetin ( 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone )

Catalog No. M27676 CAS No. 487-49-0

Ononetin is a TRPM3 channel blocker(IC50: 0.3 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ononetin
  • Note
    Research use only, not for human use.
  • Brief Description
    Ononetin is a TRPM3 channel blocker(IC50: 0.3 μM).
  • Description
    Ononetin is a TRPM3 channel blocker(IC50: 0.3 μM).(In Vitro):Administration of 1-10 μM Ononetin completely and reversibly abrogates Ca2+ entry and ionic currents through recombinantly expressed TRPM3α2 and block the pregnenolone sulphate-inducible Ca2+ entry in primary cultures of mouse or rat dorsal root ganglia (DRG) neurones.(In Vivo):Intraperitoneal injection of 10 mg/kg Ononetin completely reverses established Freund's Complete Adjuvant (FCA)-induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3-/- mice is unlikely to be caused by developmental or compensatory mechanisms.
  • Synonyms
    2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    487-49-0
  • Formula Weight
    258.3
  • Molecular Formula
    C15H14O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COc1ccc(CC(=O)c2ccc(O)cc2O)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Samuele Ciceri, et al. Synthesis of the antitumoral nucleoside capecitabine through a chemo-enzymatic approach. Tetrahedron Letters, Volume 56, Issue 43, 2015, Pages 5909-5913.
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