OSMI-3

Research use only, not for human use.

OSMI-3 is a potent and cell-permeable inhibitor of O-GlcNAc transferase (OGT) for the study of cancer and cardiovascular disease.

OSMI-3 (Compound 2b) is a potent, long-lasting, and cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-3 increases detained intron splicing in cells.

OSMI-3 (Compound 2b; 20-50 μM; 4-24 hours; HCT116 cells) treatment significantly reduces O-GlcNAc levels, and has more sustained cellular effects than OSMI-2.A decrease in HCF-1 cleavage products and the appearance of uncleaved HCF-1 in cells treated with OSMI-3 (Compound 2b) is observed. Because OGT knockdown is known to decrease cell proliferation, the effects of OSMI-3 on cell growth in culture over 96h is also monitored. Although there is no evidence of apoptosis, the reduced growth of cells over time is observed, consistent with the knockdown results.Western Blot Analysis Cell Line:HCT116 cells Concentration:20 μM, 40 μM, 50 μM Incubation Time:4 hours, 24 hours Result:Reduced O-GlcNAc levels.

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Others

Other Targets

Others

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2260791-13-5

669.77

C32H35N3O9S2

>98% (HPLC)

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[C@@H](C(N(CC1=CC=CS1)CC(OCC)=O)=O)(NS(=O)(=O)C=2C=C3C(=CC2)NC(=O)C=C3)C4=C(OCCCC(OCC)=O)C=CC=C4

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(-20℃)

With Ice Pack

≥ 2 years