OSBPL7-IN-1

CAS No. 1269826-44-9

OSBPL7-IN-1 ( —— )

Catalog No. M28764 CAS No. 1269826-44-9

OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7). OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 222 Get Quote
10MG 357 Get Quote
25MG 597 Get Quote
50MG 851 Get Quote
100MG 1152 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    OSBPL7-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7). OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression.
  • Description
    OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7). OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression.(In Vitro):OSBPL7-IN-1 (compound G; 1-10?μM) increase plasma membrane ATP-binding cassette transporter (ABCA1) in cultured human podocytes, and significantly increase ABCA1-dependent cholesterol efflux.(In Vivo):OSBPL7-IN-1 (100?mg/kg; oral gavage; daily; for 28 days) treatment normalizes proteinuria, and prevents renal function decline in mouse models of proteinuric kidney disease.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1269826-44-9
  • Formula Weight
    463.3
  • Molecular Formula
    C20H19Cl2F3N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O[C@H](CCCC1)[C@@H]1NC(c(cn1)cc(-c(cc2)cc(Cl)c2Cl)c1OCC(F)(F)F)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Atta-Ur-Rahman, Shabbir M, Khan AM, Hayat S, Nasreen A, Malik S, Choudhary MI. (1999) Chemical constituents from marine organisms. Natural Product Letters, 13, 255-261.
molnova catalog
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