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ONO-RS-082

CAS No. 99754-06-0

ONO-RS-082( —— )

Catalog No. M27471 CAS No. 99754-06-0

ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ONO-RS-082
  • Note
    Research use only, not for human use.
  • Brief Description
    ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor.?
  • Description
    ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor.?(In Vitro):ONO-RS-082 at 3.5 μM was able to inhibit epinephrine-stimulated thromboxane production in human platelets.?ONO-RS-082 could also disrupt endosome tubule formation and maintenance of the Golgi complex.
  • In Vitro
    Cell Viability Assay Cell Line:A549 lung epithelial cell lines Concentration:10 μM Incubation Time:2-h pretreatment Result:Completely blocked HXA3-mediated PAO1-induced PMN transepithelial migration. Largely prevented PAO1-induced PGE2 release.
  • In Vivo
    Animal Model:MCT- pulmonary hypertension (PH) rat model Dosage:50 mg/kg/day Administration:Result:Reduced the development of PH in the MCT-PH model for long-term.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    99754-06-0
  • Formula Weight
    371.86
  • Molecular Formula
    C21H22ClNO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (268.92 mM)
  • SMILES
    CCCCCc1ccc(\C=C\C(=O)Nc2cc(Cl)ccc2C(O)=O)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Che L, et al. Feprazone Displays Antiadipogenesis and Antiobesity Capacities in in Vitro 3 T3-L1 Cells and in Vivo Mice. ACS Omega. 2021 Mar 7;6(10):6674-6680.
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