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ONO-RS-082
CAS No. 99754-06-0
ONO-RS-082( —— )
Catalog No. M27471 CAS No. 99754-06-0
ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | Get Quote |
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| 5MG | 65 | Get Quote |
|
| 10MG | 110 | Get Quote |
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| 25MG | 212 | Get Quote |
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| 50MG | 385 | Get Quote |
|
| 100MG | 575 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameONO-RS-082
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NoteResearch use only, not for human use.
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Brief DescriptionONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor.?
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DescriptionONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor.?(In Vitro):ONO-RS-082 at 3.5 μM was able to inhibit epinephrine-stimulated thromboxane production in human platelets.?ONO-RS-082 could also disrupt endosome tubule formation and maintenance of the Golgi complex.
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In VitroCell Viability Assay Cell Line:A549 lung epithelial cell lines Concentration:10 μM Incubation Time:2-h pretreatment Result:Completely blocked HXA3-mediated PAO1-induced PMN transepithelial migration. Largely prevented PAO1-induced PGE2 release.
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In VivoAnimal Model:MCT- pulmonary hypertension (PH) rat model Dosage:50 mg/kg/day Administration:Result:Reduced the development of PH in the MCT-PH model for long-term.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number99754-06-0
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Formula Weight371.86
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Molecular FormulaC21H22ClNO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (268.92 mM)
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SMILESCCCCCc1ccc(\C=C\C(=O)Nc2cc(Cl)ccc2C(O)=O)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Che L, et al. Feprazone Displays Antiadipogenesis and Antiobesity Capacities in in Vitro 3 T3-L1 Cells and in Vivo Mice. ACS Omega. 2021 Mar 7;6(10):6674-6680.
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