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OGG1-IN-O8

CAS No. 350997-39-6

OGG1-IN-O8( —— )

Catalog No. M21645 CAS No. 350997-39-6

OGG1-IN-O8 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1;IC50 : 0.35 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    OGG1-IN-O8
  • Note
    Research use only, not for human use.
  • Brief Description
    OGG1-IN-O8 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1;IC50 : 0.35 μM).
  • Description
    OGG1-IN-O8 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1;IC50 : 0.35 μM).
  • In Vitro
    OGG1-IN-08 (50 μM) inhibits different DNA glycosylases activities, it inhibits?nei endonuclease VIII-like 1 DNA glycosylase (NEIL1)(84.56%), endonuclease III-like (NTH1)(63.09%), andFpg (91.74%), respectively.OGG1-IN-08 (10 μM) has a inhibitory OGG1 lyase activity on a substrate containing an AP site compared with the no inhibitor control.OGG1-IN-08 (10 μM) decreases the number of bases released into solution by OGG1 for both the 8-oxo-Gua and FapyGua compared with the no inhibitor.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    8-oxoguanine DNA glycosylase 1 (OGG1)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    350997-39-6
  • Formula Weight
    261.12
  • Molecular Formula
    C9H6Cl2N2OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (95.74 mM)
  • SMILES
    NNC(=O)c1sc2cccc(Cl)c2c1Cl
  • Chemical Name
    34-Dichloro-benzo[b]thiophene-2-carboxylic acid hydrazide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lloyd R.S. Mccullough A.K. and Donley N.?Small molecule inhibitors of 8-oxoguanine DNA glycosylase-1 (OGG1).?(2016).
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