OG-L002 ( OG L002 )

Catalog No. M11464 CAS No. 1357302-64-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

OG-L002
Note

Research use only, not for human use.
Brief Description

OG-L002 is a novel selective LSD1 inhibitor with IC50 of 20 nM.
Description

OG-L002 is a novel selective LSD1 inhibitor with IC50 of 20 nM; demonstrates significant potency both in inhibition of HSV IE gene expression and in suppression of viral reactivation from latency in a mouse ganglion explant model; also suppresses the expression of the initial class of hCMV and adenovirus genes in vitro; reduces the induction of TNF-α mRNA in splenocytes from mice.
Synonyms

OG L002
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

LSD1
Research Area

Infection
Indication

——

CAS Number

1357302-64-7
Formula Weight

225.30
Molecular Formula

C15H15NO
Purity

>98% (HPLC)
Solubility

DMSO: 42 mg/mL (186.4 mM); Ethanol: 16 mg/mL (71 mM); Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

OC1=CC(C2=CC=C([C@@H]3[C@@H](N)C3)C=C2)=CC=C1
Chemical Name

4'-[(1R,2S)-2-aminocyclopropyl]-[1,1'-biphenyl]-3-ol

1. Seifermann M, et al. DNA Repair (Amst). 2017 Oct;58:13-20.
2. Liang Y, et al. MBio. 2013 Feb 5;4(1):e00558-12.

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