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OATD-01
CAS No. 2088453-21-6
OATD-01 ( —— )
Catalog No. M28787 CAS No. 2088453-21-6
OATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 67 | Get Quote |
|
| 5MG | 110 | Get Quote |
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| 10MG | 178 | Get Quote |
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| 25MG | 335 | Get Quote |
|
| 50MG | 500 | Get Quote |
|
| 100MG | 705 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameOATD-01
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NoteResearch use only, not for human use.
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Brief DescriptionOATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase).
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DescriptionOATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase).(In Vitro):The Ki values for hCHIT1,mCHIT1, hAMCase and mAMCase are 17.3 nM, 26.05 nM, 4.8 nM and 5.7 nM, respectively. These Ki values reveals good correlation with earlier established IC50 data, which are 23 nM, 28 nM, 9 nM and 7.8 nM, respectively. OATD-01 shows excellect PK profile in multiple species and is selectivity against a panel of other off-targets.(In Vivo):OATD-01 given orally once daily in a range of doses between 30 and 100 mg/kg showed significant antifibrotic efficacy in an animal model of bleomycin-induced pulmonary fibrosis.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPDE3A
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Research Area——
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Indication——
Chemical Information
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CAS Number2088453-21-6
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Formula Weight390.9
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Molecular FormulaC19H27ClN6O
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Purity>98% (HPLC)
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Solubility——
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SMILESC[C@@H](C1)OC[C@H](Cc(cc2)ccc2Cl)N1C(CC1)CCN1c1nc(N)n[nH]1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ai Y, et al. An alkaloid initiates phosphodiesterase 3A-schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity. Nat Commun. 2020 Jun 26;11(1):3236.
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