Norethindrone

CAS No. 68-22-4

Norethindrone( Norethisterone | NSC 9564 )

Catalog No. M15605 CAS No. 68-22-4

Norethindrone is a synthetic progestin, which mimic the actions of the endogenous ovarian hormone progesterone.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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50MG 34 In Stock
100MG 48 In Stock
200MG 57 In Stock
500MG 73 In Stock
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Biological Information

  • Product Name
    Norethindrone
  • Note
    Research use only, not for human use.
  • Brief Description
    Norethindrone is a synthetic progestin, which mimic the actions of the endogenous ovarian hormone progesterone.
  • Description
    Norethindrone is a synthetic progestin, which mimic the actions of the endogenous ovarian hormone progesterone.(In Vitro):Norethindrone acetate could be a cost-effective alternative with relatively mild side effects in the treatment of symptomatic endometriosis. Subjects treated with norethindrone acetate obtain dysmenorrhea and noncyclic pelvic pain relief. Norethindrone acetate alone is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis. Post-Norethindrone acetate bleeding scores are improved regardless of prior hormonal regimen, and post-Norethindrone acetate pain scores improved in all patients except for those previously prescribed GnRH-agonist plus add-back. Norethindrone acetate shows low acute toxicity in experimental animals and is consistent with the lack of toxicity seen in humans. Administration of norethindrone acetate alone to rodents at several multiples of the human dose results in no treatment related mortality, hematological changes, behavioral changes, or organ pathology. Norethindrone acetate administration leads to significant and proportional reductions of the concentrations of triglycerides, cholesterol and phospholipids of plasma lipoproteins of density <1.006 of rats fed a high carbohydrate diet. Norethindrone acetate (0.1 mM) also significantly inhibits the incorporation of both palmitate and glycerol into triglycerides of isolated hepatocytes from fed rats.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Norethisterone | NSC 9564
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    ER
  • Research Area
    Endocrinology
  • Indication
    ——

Chemical Information

  • CAS Number
    68-22-4
  • Formula Weight
    298.42
  • Molecular Formula
    C20H26O2
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 5 mg/mL (16.75 mM); DMSO: 60 mg/mL (201.05 mM)
  • SMILES
    C[C@]12CC[C@H]3[C@@H](CCC4=CC(CC[C@H]34)=O)[C@@H]1CC[C@@]2(O)C#C
  • Chemical Name
    (8R,9S,10R,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mendoza-Rodriguez CA, et al. Contraception. 1999 May;59(5):339-43.
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