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Nomilin

CAS No. 1063-77-0

Nomilin( Nomilin )

Catalog No. M17792 CAS No. 1063-77-0

Nomilin is naturally occurring triterpenoids, have immunomodulatory activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Nomilin
  • Note
    Research use only, not for human use.
  • Brief Description
    Nomilin is naturally occurring triterpenoids, have immunomodulatory activity.
  • Description
    Nomilin is an inducer of phase II detoxifying enzymes, showing anti-proliferative active on cultured human breast cancer cells.(In Vitro):Nomilin treatment significantly mitigated cell death and decreased lactate dehydrogenase (LDH) release and ROS production in SH-SY5Y cells induced by oxygen-glucose deprivation (OGD), which was almost abolished by Nrf2 knockdown.(In Vivo):Nomilin attenuated blood-brain barrier (BBB) disruption in MCAO rats, which might be associated with alleviating the loss of tight junction proteins, including ZO-1 and occludin-5.
  • In Vitro
    Nomilin treatment significantly mitigated cell death and decreased lactate dehydrogenase (LDH) release and ROS production in SH-SY5Y cells induced by oxygen-glucose deprivation (OGD), which was almost abolished by Nrf2 knockdown.
  • In Vivo
    Nomilin attenuated blood-brain barrier (BBB) disruption in MCAO rats, which might be associated with alleviating the loss of tight junction proteins, including ZO-1 and occludin-5.
  • Synonyms
    Nomilin
  • Pathway
    Immunology/Inflammation
  • Target
    LTR
  • Recptor
    MAPK
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1063-77-0
  • Formula Weight
    514.57
  • Molecular Formula
    C28H34O9
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (194.34 mM)
  • SMILES
    CC(=O)OC5CC(=O)O[C@@](C)(C)[C@@H]6CC(=O)[C@]3(C)[C@H](CC[C@@]2(C)[C@@H](OC(=O)[C@H]1O[C@]123)c4ccoc4)[C@@]56C
  • Chemical Name
    1-(Acetyloxy)-1,2-dihydroobacunoic acid e-lactone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Battinelli L, et al. Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells.[J]. Planta Medica, 2003, 69(10):910-913.
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