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Nitroflurbiprofen

CAS No. 158836-71-6

Nitroflurbiprofen ( HCT 1206; NO-flurbiprofen; Nitroxybutyl flurbiprofen )

Catalog No. M26772 CAS No. 158836-71-6

Nitroflurbiprofen is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Nitroflurbiprofen
  • Note
    Research use only, not for human use.
  • Brief Description
    Nitroflurbiprofen is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.
  • Description
    Nitroflurbiprofen is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.(In Vivo):Nitroflurbiprofen (45 mg/kg; i.p.) improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors.
  • Synonyms
    HCT 1206; NO-flurbiprofen; Nitroxybutyl flurbiprofen
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    Influenza A and B; Nucleoside Antimetabolite/Analog
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    158836-71-6
  • Formula Weight
    361.4
  • Molecular Formula
    C19H20FNO5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C(=O)OCCCCO[N+]([O-])=O)c1ccc(c(F)c1)-c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jakeman KJ, et, al. Efficacy of 2'-deoxy-2'-fluororibosides against influenza A and B viruses in ferrets. Antimicrob Agents Chemother. 1994 Aug;38(8):1864-7.
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