Nicotredole

CAS No. 29876-14-0

Nicotredole ( Tryptamide )

Catalog No. M28294 CAS No. 29876-14-0

Nicotredole (Tryptamide) is an orally active anti-inflammatory and analgesic agent. Nicotredole exhibits evident antiinflammatory effects of potency comparable with Phenylbutazone. Nicotredole has only weak ulcerogenic activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 43 Get Quote
5MG 72 Get Quote
10MG 110 Get Quote
25MG 188 Get Quote
50MG 295 Get Quote
100MG 444 Get Quote
500MG 963 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Nicotredole
  • Note
    Research use only, not for human use.
  • Brief Description
    Nicotredole (Tryptamide) is an orally active anti-inflammatory and analgesic agent. Nicotredole exhibits evident antiinflammatory effects of potency comparable with Phenylbutazone. Nicotredole has only weak ulcerogenic activity.
  • Description
    Nicotredole (Tryptamide) is an orally active anti-inflammatory and analgesic agent. Nicotredole exhibits evident antiinflammatory effects of potency comparable with Phenylbutazone. Nicotredole has only weak ulcerogenic activity.(In Vitro):Nicotredole inhibits prostaglandin synthetase activity in vitro . (In Vivo):Nicotredole produces antiinflammatory effects in carrageenin-induced rat paw oedema . Nicotredole reverses pyrogen-induced hyperthermia in rats, elicits analgesic effects in rats, prolongs the time of hexobarbital sleep in rats and inhibits locomotor activity in rats and mice . Nicotredole (i.p.) has LD50s of 1260 mg/kg and 1980 mg/kg for male rats and male mice, respectively . Nicotredole (p.o.) has LD50s of 8.5 g/kg and 9.3 g/kg for male rats and male mice, respectively . Nicotredole (25 mg/kg; p.o. or i.p.) undergoes fast absorption (t 1/2 =4.92-17.5 min) and elimination (t 1/2 =55.72-74.52 min), can reach C max (11-13 μg/cm 3 ) after 30 min, and gives AUC values in the range of 21.40-27.30 (μgh/cm 3 ) .
  • Synonyms
    Tryptamide
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    29876-14-0
  • Formula Weight
    265.3
  • Molecular Formula
    C16H15N3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NCCc1c[nH]c2ccccc12)c1cccnc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Barlow RB, Burston KN. A comparison of cinobufotenine (the quaternary derivative of 5-HT) and some related compounds with coryneine (the quaternary derivative of dopamine) on the frog rectus, guinea-pig ileum and rat fundus strip preparations. Br J Pharmacol. 1980 Aug;69(4):597-600.
molnova catalog
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