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Niaprazine
CAS No. 27367-90-4
Niaprazine ( Nopron; 1709 CERM )
Catalog No. M28104 CAS No. 27367-90-4
Niaprazine is a histamine H1-receptor antagonist with marked sedative properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 51 | In Stock |
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| 5MG | 80 | In Stock |
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| 10MG | 132 | In Stock |
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| 25MG | 223 | In Stock |
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| 50MG | 332 | In Stock |
|
| 100MG | 489 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNiaprazine
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NoteResearch use only, not for human use.
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Brief DescriptionNiaprazine is a histamine H1-receptor antagonist with marked sedative properties.
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DescriptionNiaprazine is a histamine H1-receptor antagonist with marked sedative properties.(In Vitro):Niaprazine, particularly the (+)stereoisomer, has a higher affinity for alpha 1 (Ki = 77 nM) and 5-HT2 (Ki = 25 nM) binding sites, but is poorly recognized by 5-HT1A and 5-HT1B binding sites (Ki sigma mciroM).(In Vivo):Niaprazine (60 mg/kg i.p.) increased rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Rat brain 5-hydroxytryptamine (5-HT) levels were unchanged. Niaprazine also produced a short-lasting depletion of rat brain noradrenaline (NA) and dopamine (DA). Pretreatment with alpha-phenyl-alpha-propyl-benzeneacetic acid, 2-(diethylamino) ethyl ester hydrochloride (SKF 525A) (75 mg/kg i.p.) potentiated the increase in 5-HIAA and depletion of catecholamines produced 1 hr after niaprazine, but abolished the reduction in 5-HIAA produced 8 hr after the drug.
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SynonymsNopron; 1709 CERM
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number27367-90-4
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Formula Weight356.4
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Molecular FormulaC20H25FN4O
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(CCN1CCN(CC1)c1ccc(F)cc1)NC(=O)c1cccnc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Gribkova IV, et al. Kaolin, used to trigger coagulation in thrombin generation test, increases sensitivity of the method in hemophilia patients. Blood Coagul Fibrinolysis. 2020 Apr;31(3):193-197.
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