Niaprazine

CAS No. 27367-90-4

Niaprazine ( Nopron; 1709 CERM )

Catalog No. M28104 CAS No. 27367-90-4

Niaprazine is a histamine H1-receptor antagonist with marked sedative properties.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 51 In Stock
5MG 80 In Stock
10MG 132 In Stock
25MG 223 In Stock
50MG 332 In Stock
100MG 489 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    Niaprazine
  • Note
    Research use only, not for human use.
  • Brief Description
    Niaprazine is a histamine H1-receptor antagonist with marked sedative properties.
  • Description
    Niaprazine is a histamine H1-receptor antagonist with marked sedative properties.(In Vitro):Niaprazine, particularly the (+)stereoisomer, has a higher affinity for alpha 1 (Ki = 77 nM) and 5-HT2 (Ki = 25 nM) binding sites, but is poorly recognized by 5-HT1A and 5-HT1B binding sites (Ki sigma mciroM).(In Vivo):Niaprazine (60 mg/kg i.p.) increased rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Rat brain 5-hydroxytryptamine (5-HT) levels were unchanged. Niaprazine also produced a short-lasting depletion of rat brain noradrenaline (NA) and dopamine (DA). Pretreatment with alpha-phenyl-alpha-propyl-benzeneacetic acid, 2-(diethylamino) ethyl ester hydrochloride (SKF 525A) (75 mg/kg i.p.) potentiated the increase in 5-HIAA and depletion of catecholamines produced 1 hr after niaprazine, but abolished the reduction in 5-HIAA produced 8 hr after the drug.
  • Synonyms
    Nopron; 1709 CERM
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    27367-90-4
  • Formula Weight
    356.4
  • Molecular Formula
    C20H25FN4O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(CCN1CCN(CC1)c1ccc(F)cc1)NC(=O)c1cccnc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gribkova IV, et al. Kaolin, used to trigger coagulation in thrombin generation test, increases sensitivity of the method in hemophilia patients. Blood Coagul Fibrinolysis. 2020 Apr;31(3):193-197.
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