Neurotensin(8-13)

Research use only, not for human use.

Neurotensin (8-13) is a neuropeptide that corresponds to the C-terminal residues 8-13 of neurotensin that binds to rat synaptic membranes with a Ki value of 13 nM.1 It induces contraction of guinea pig ileum (EC50 = 25 nM) and induces contraction of rat fundus equipotently to full length neurotensin (EC50s = 1.29 and 1.58 nM, respectively).

Neurotensin (8-13) is a neuropeptide that corresponds to the C-terminal residues 8-13 of neurotensin that binds to rat synaptic membranes with a Ki value of 13 nM.1 It induces contraction of guinea pig ileum (EC50 = 25 nM) and induces contraction of rat fundus equipotently to full length neurotensin (EC50s = 1.29 and 1.58 nM, respectively).(In Vitro):Receptor internalization induced by Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density. The receptor downregulation in response to high extracellular concentrations of the peptide has been described for Neurotensin (NT) in HT-29 cells and in rat primary cultured neurons. Reappearance of the receptors on the cell surface is also different.

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GPCR/G Protein

Neurotensin Receptor

NTR1

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60482-95-3

816.99

C38H64N12O8

>98% (HPLC)

H2O : 50 mg/mL (61.20 mM; Need ultrasonic)

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Sequence:Arg-Arg-Pro-Tyr-Ile-Leu

(-20℃)

With Ice Pack

≥ 2 years