Netupitant

CAS No. 290297-26-6

Netupitant ( AGE94200; AGE 94200;Ro 67-3189;Netupitant )

Catalog No. M18372 CAS No. 290297-26-6

Netupitant is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 42 In Stock
10MG 61 In Stock
25MG 110 In Stock
50MG 189 In Stock
100MG 340 In Stock
200MG 502 In Stock
500MG 797 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Netupitant
  • Note
    Research use only, not for human use.
  • Brief Description
    Netupitant is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).
  • Description
    Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively binds to and blocks the activity of the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV).
  • Synonyms
    AGE94200; AGE 94200;Ro 67-3189;Netupitant
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    NK1
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    290297-26-6
  • Formula Weight
    578.59
  • Molecular Formula
    C30H32F6N4O
  • Purity
    98%
  • Solubility
    DMSO : 23.2 mg/mL; 40.10 mM
  • SMILES
    Cc1ccccc1c1cc(ncc1N(C)C(=O)C(C)(C)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)N1CCN(CC1)C
  • Chemical Name
    2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-(6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)propanamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Rizzi A,etal.In vitro and in vivo pharmacological characterization of the novel NK receptor selective antagonist Netupitant.Peptides. 2012 Sep;37(1):86-97.
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