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Netupitant
CAS No. 290297-26-6
Netupitant ( AGE94200; AGE 94200;Ro 67-3189;Netupitant )
Catalog No. M18372 CAS No. 290297-26-6
Netupitant is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
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| 10MG | 61 | In Stock |
|
| 25MG | 110 | In Stock |
|
| 50MG | 189 | In Stock |
|
| 100MG | 340 | In Stock |
|
| 200MG | 502 | In Stock |
|
| 500MG | 797 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNetupitant
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NoteResearch use only, not for human use.
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Brief DescriptionNetupitant is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).
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DescriptionNetupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively binds to and blocks the activity of the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV).
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SynonymsAGE94200; AGE 94200;Ro 67-3189;Netupitant
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PathwayOthers
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TargetOther Targets
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RecptorNK1
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number290297-26-6
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Formula Weight578.59
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Molecular FormulaC30H32F6N4O
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Purity98%
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SolubilityDMSO : 23.2 mg/mL; 40.10 mM
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SMILESCc1ccccc1c1cc(ncc1N(C)C(=O)C(C)(C)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)N1CCN(CC1)C
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Chemical Name2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-(6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)propanamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Rizzi A,etal.In vitro and in vivo pharmacological characterization of the novel NK receptor selective antagonist Netupitant.Peptides. 2012 Sep;37(1):86-97.
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