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Neticonazole

CAS No. 130726-68-0

Neticonazole( —— )

Catalog No. M34750 CAS No. 130726-68-0

Neticonazole (SS717) is an imidazole derivative with antifungal activity that inhibits exosome secretion.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Neticonazole
  • Note
    Research use only, not for human use.
  • Brief Description
    Neticonazole (SS717) is an imidazole derivative with antifungal activity that inhibits exosome secretion.
  • Description
    Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole has anti-infection and anti-cancer effects.
  • In Vitro
    Western Blot Analysis Cell Line:C4-2B cells Concentration:10 μM Incubation Time:48 hours Result:Decreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels.
  • In Vivo
    Animal Model:Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells Dosage:1 ng/kg, 10 ng/kg and 100 ng/kg Administration:Oral gavage; daily; for 15 days Result:Significantly improved the survival of IDB mice with CRC xenograft tumors.
  • Synonyms
    ——
  • Pathway
    Microbiology/Virology
  • Target
    Antifungal
  • Recptor
    Antifungal
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    130726-68-0
  • Formula Weight
    302.43
  • Molecular Formula
    C17H22N2OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (826.64 mM; Ultrasonic )1M HCl : 100 mg/mL (330.66 mM; Ultrasonic; (HCL，pH≈1))
  • SMILES
    C(=C\SC)(\C1=C(OCCCCC)C=CC=C1)/N2C=CN=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tsuboi R, et al. Hyperkeratotic chronic tinea pedis treated with neticonazole cream. Neticonazole Study Group. Int J Dermatol. 1996 May;35(5):371-3.?
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