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Nelotanserin
CAS No. 839713-36-9
Nelotanserin ( APD-125;RVT-102 )
Catalog No. M16119 CAS No. 839713-36-9
A potent, selective 5-HT2A inverse agonist with pKi of 9.2; displays >30- and 5000-fold selectivity compared with 5-HT2C and 5-HT2B receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | In Stock |
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| 5MG | 72 | In Stock |
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| 10MG | 110 | In Stock |
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| 25MG | 178 | In Stock |
|
| 50MG | 332 | In Stock |
|
| 100MG | 494 | In Stock |
|
| 500MG | 1071 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNelotanserin
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective 5-HT2A inverse agonist with pKi of 9.2; displays >30- and 5000-fold selectivity compared with 5-HT2C and 5-HT2B receptors.
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DescriptionA potent, selective 5-HT2A inverse agonist with pKi of 9.2; displays >30- and 5000-fold selectivity compared with 5-HT2C and 5-HT2B receptors; prevents DOI-induced hypolocomotion and increases sleep consolidation; orally active.Depression Phase 2 Discontinued
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SynonymsAPD-125;RVT-102
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research AreaNeurological Disease
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IndicationDepression
Chemical Information
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CAS Number839713-36-9
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Formula Weight437.24
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Molecular FormulaC18H15BrF2N4O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 32 mg/mL
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SMILESO=C(NC1=CC=C(F)C=C1F)NC2=CC=C(OC)C(C3=C(Br)C=NN3C)=C2
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Chemical NameUrea, N-[3-(4-bromo-1-methyl-1H-pyrazol-5-yl)-4-methoxyphenyl]-N'-(2,4-difluorophenyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Teegarden BR, et al. J Med Chem. 2010 Mar 11;53(5):1923-36.
2. Al-Shamma HA, et al. J Pharmacol Exp Ther. 2010 Jan;332(1):281-90.
2. Al-Shamma HA, et al. J Pharmacol Exp Ther. 2010 Jan;332(1):281-90.
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