Nelotanserin ( APD-125;RVT-102 )

Catalog No. M16119 CAS No. 839713-36-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Nelotanserin
Note

Research use only, not for human use.
Brief Description

A potent, selective 5-HT2A inverse agonist with pKi of 9.2; displays >30- and 5000-fold selectivity compared with 5-HT2C and 5-HT2B receptors.
Description

A potent, selective 5-HT2A inverse agonist with pKi of 9.2; displays >30- and 5000-fold selectivity compared with 5-HT2C and 5-HT2B receptors; prevents DOI-induced hypolocomotion and increases sleep consolidation; orally active.Depression Phase 2 Discontinued
Synonyms

APD-125;RVT-102
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT Receptor
Research Area

Neurological Disease
Indication

Depression

CAS Number

839713-36-9
Formula Weight

437.24
Molecular Formula

C18H15BrF2N4O2
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 32 mg/mL
SMILES

O=C(NC1=CC=C(F)C=C1F)NC2=CC=C(OC)C(C3=C(Br)C=NN3C)=C2
Chemical Name

Urea, N-[3-(4-bromo-1-methyl-1H-pyrazol-5-yl)-4-methoxyphenyl]-N'-(2,4-difluorophenyl)-

1. Teegarden BR, et al. J Med Chem. 2010 Mar 11;53(5):1923-36.
2. Al-Shamma HA, et al. J Pharmacol Exp Ther. 2010 Jan;332(1):281-90.

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